Inherited defective genes also can cause the condition. For some adults who develop sporadic ataxia, no specific cause can be found.
'Sporadic' ataxia implies there is no family history. Acquired progressive ataxias can be immune mediated (eg, paraneoplastic spinocerebellar degeneration.
The diagnosis of sporadic adult onset ataxia is a challenging task since a large collection of hereditary and non-hereditary disorders should be.
Differential diagnosis of hereditary ataxia includes acquired, non-genetic .. The most common adult-onset autosomal dominant ataxias are SCA1, SCA2, SCA3.